Prednisone and zinc. The primary endpoint was overall survival at 90 days.

Prednisone and zinc Combining prednisone and doxycycline may increase the risk of gastrointestinal side effects and reduce the effectiveness of doxycycline. Similarly, due to steroid’s immune-suppressing properties, extra amounts of vitamin C or zinc could help bolster your immunity in response to Prednisone usage. Dec 17, 2024 · Prednisone side effects include retaining fluid, mood changes and a weak immune system. Vitamin c plus zinc is used to treat Vitamin/Mineral Supplementation and Deficiency. Herbal remedies rich in antioxidants, such as stinging nettle root and turmeric, have also shown potential in preventing or managing symptoms of chronic inflammatory conditions. Feb 14, 2023 · Zinc is a mineral essential for many functions in your body. Prednisone was mixed into the control diet at weekly intervals to ensure that the animals received either 0. Zinc may therefore be useful for dogs with chronic hepatitis with moderate fibrosis, especially if mild to moderately increased copper is present. Zinc lozenges can be taken at the first sign of a cold or flu to help alleviate symptoms. Always remember to consult with your Prednisone weight gain happens to 70% of prednisone patients, and many struggle accepting their new change in appearance. prednisone 40 mg PO daily for 30 days. Turmeric can interfere with the metabolism of prednisone and decrease its effectiveness. This report displays the potential drug interactions for the following 2 drugs: prednisone; zinc chloride; Edit list (add/remove drugs) Consumer; Professional; Interactions between your drugs Given that the loss of taste is a symptom of zinc deficiency, the effects of captopril on taste acuity and zinc status were investigated in hypertensive patients on long-term (>6 months), high-dose (266 mg/d) captopril treatment, short-term (<6 months), lower-dose (100 mg/d) treatment, and controls not taking captopril. Urinary excretion of zinc and nitrogen increased in proportion to the doses of prednisone. The most commonly reported adverse effects associated with corticosteroid use include fluid retention, alteration in glucose tolerance, high blood pressure, behavior and mood changes, increased appetite and weight gain. In nine kidney-transplanted patients, receiving prednisone as part of the immunosuppression, serum zinc and urinary zinc excretion were measured for a period of 5-7 weeks after the transplantation. CBD is another potent inhibitor of these enzymes, potentially leading to higher blood levels of prednisone and longer times that the drug spends in the body per dose. Prednisone is used to treat the following conditions: Acute Lymphocytic Leukemia; Adrenocortical Insufficiency; Allergic Reactions; Allergic Rhinitis; Allergies; Amyloidosis; Ankylosing Spondylitis; Aspiration Pneumonia; Asthma 3 likes, 0 comments - prednisonepharmacist on October 31, 2024: "Prednisone and Zinc: The Side Effects of Low Zinc Levels #prednisone #prednisonesideeffects #steroids #steroidsideeffects #glucocorticoid #zinc". Participants were followed for 180 days. Applies to prednisone: compounding powder, oral delayed release tablet, oral solution, oral tablet. It has been previously studied in AH. More easily absorbed forms of zinc are zinc picolinate, zinc citrate, zinc acetate, zinc glycerate, and zinc monomethionine. Gastrointestinal perforation is a potentially fatal condition and medical emergency where a hole forms all the way through the stomach or intestine. Reduced height attainment was significant May 18, 2024 · Use of prednisone in patients with severe alcohol-associated hepatitis (SAH) results in significantly better overall and transplant-free survival at 90 days and a lower incidence of acute kidney injury (AKI) when compared with the use of anakinra plus zinc, results of a study have shown. You may experience reduced absorption of zinc acetate in the presence of certain foods. Prednisone is used to treat allergic disorders, skin conditions, ulcerative colitis, Crohn’s disease, arthritis, lupus, psoriasis, asthma, chronic obstructive pulmonary disease (COPD) and many more conditions. Potassium In addition to vitamins, corticosteroids can deplete vital minerals in the body. High doses of zinc taken over the long term (50 mg or more per day for 10 weeks or longer) can also cause copper deficiency. Using adalimumab together with predniSONE may increase the risk of serious and potentially life-threatening infections. Aug 9, 2019 · Anakinra is indicated for reduction in signs and symptoms and slowing the progression of structural damage in moderately to severely active rheumatoid arthritis. Prednisone is also used to treat other conditions in patients with normal corticosteroid levels. This means that taking magnesium supplements alongside prednisone may reduce the effectiveness of the magnesium or lead to lower levels of absorption. Different minerals can compete for absorption in your digestive system when taken at the same time. Zicam has active ingredients of zinc gluconate. Doctors and pharmacists almost never discuss drug-induced nutrient depletions with patients even though the fix is easy–simply take dietary supplements to replenish what’s lost. It is often used in rheumatoid arthritis. domized to receive either daily anakinra 100 mg subcutaneously for 14 days plus daily zinc sulfate 220 mg orally for 90 days, or daily prednisone 40 mg orally for 30 days. Prednisone is used alone or with other medications to treat the symptoms of low corticosteroid levels (lack of certain substances that are usually produced by the body and are needed for normal body functioning). This report displays the potential drug interactions for the following 2 drugs: prednisone; zinc gluconate; Edit list (add/remove drugs) Consumer; Professional; Interactions between your drugs Zinc Interactions. Zinc sulfate is the least expensive form, but it is the least easily absorbed and may cause stomach upset. By consuming enough zinc through Nutranize Zone or zinc-rich foods, individuals on prednisone can potentially strengthen their immune system, assist in wound healing, and support growth and development. If you must take copper and also take zinc, space the two out by at least two hours, Dr. There are 102 drugs known to interact with Calcium, Magnesium and Zinc (multivitamin with minerals). Bread, bran, hard boiled eggs, coffee, and milk may significantly decrease the absorption of zinc acetate. Prednisone is used to treat the following conditions: Acute Lymphocytic Leukemia; Adrenocortical Insufficiency; Allergic Reactions; Allergic Rhinitis; Allergies; Amyloidosis; Ankylosing Spondylitis; Aspiration Pneumonia; Asthma To assess interrelationships between asthma, corticosteroid therapy, growth, and zinc status in children, measurements of height, zinc and copper in serum and hair, taste acuity, and dietary intakes of energy, protein, zinc, and copper were analyzed for 29 asthmatic, 11 prednisone-treated asthmatic, and 21 non-asthmatic subjects, 6 to 20 years old. Understanding Prednisone: Your Guide to Buying 20mg, 10mg, and 5mg Tablets Online. Jan 5, 2025 · See More Information Regarding Zinc Prednisone Overview. Nov 26, 2024 · Prednisone is commonly prescribed to treat several conditions. There are 147 drugs known to interact with Zinc (zinc sulfate), along with 2 disease interactions. A total of 605 drugs are known to interact with prednisone. Doxycycline is an antibiotic used to treat bacterial infections. Selenium, sodium and zinc can be depleted while taking a corticosteroid like prednisone. APPROACH AND RESULTS: Data from 147 participants in a multicenter Nov 9, 2022 · WASHINGTON — Prednisone induced a higher 90-day survival rate and lower incidence of acute kidney injury compared with anakinra and zinc sulfate in patients with severe alcohol-associated Article at-a-glance: Fifty-five percent of Americans now take at least one drug and almost 12% take five or more prescriptions drugs. This report displays the potential drug interactions for the following 2 drugs: prednisone; Zinc-220 (zinc sulfate) Edit list (add/remove drugs) Consumer; Professional; Interactions between your drugs Prednisone is broken down by the cytochrome P450 3A4 and turmeric blocks that, so the prednisone won’t break down properly. It works on the immune system to help relieve swelling, redness, itching, and allergic reactions. The HPA axis helps control zinc levels, so when someone takes prednisone, zinc levels can fall. Take zinc acetate on an empty stomach 1 hour before or 2 hours after a meal unless otherwise directed by your doctor. Can I Take Zinc With Prednisone Prednisone and Zinc: The Side Effects of Low Zinc Levels#prednisone #prednisonesideeffects #steroids #steroidsideeffects #glucocorticoid #zinc #shorts Vitamin C plus Zinc. It is often used in herpes labialis (oral herpes simplex). If this action happens in people, it might prolong prednisone activity and possibly increase prednisone-related side effects. All study drugs were stopped for uncontrolled infection or >−5 point increase in MELD score. Of the total drug interactions, 6 are major, 92 are moderate, and 4 are minor. We characterize the clinical factors and potential mechanisms associated with AKI development in that trial. Feb 27, 2023 · For healthcare professionals. Zinc supplementation reverses the clinical signs of zinc deficiency in participants with alcoholic liver disease. Prednisone is a corticosteroid (cortisone-like medicine or steroid). Nov 27, 2020 · The therapy based on CsA, everolimus and prednisone led to a decline in the levels of iron in bone, zinc in teeth, and molybdenum in the bone and teeth of mothers, while in the offspring, it caused a decline of bone potassium, with a decrease in iron and increase of molybdenum in teeth. Megan had to take prednisone herself for an autoimmune condition so understands what it feels like to suffer prednisone side effects and made it her mission to counteract them as the Prednisone Pharmacist. Zinc plus lozenges is used to treat Vitamin/Mineral Supplementation and Deficiency. Of the total drug interactions, 4 are major, 36 are moderate, and 107 are minor. Oct 7, 2024 · Prednisone and other corticosteroids are inhibitors of the cytochrome P450 enzyme CYP3A, which affects how the liver metabolizes materials. To assess interrelationships between asthma, corticosteroid therapy, growth, and zinc status in children, measurements of height, zinc and copper in serum and hair, taste acuity, and dietary intakes of energy, protein, zinc,and copper were analyzed for 29 asthmatic, 11 prednisone-treated asthmatic, … Immunosuppressant medications-- Since zinc may make the immune system stronger, it should not be taken with corticosteroids (such a prednisone), cyclosporine, or other medications intended to suppress the immune system. Absorption: Prednisone can interfere with the absorption of certain minerals, including magnesium. Sep 30, 2024 · Natural prednisone alternatives include vitamins C, D3, B5, zinc, and omega-3 fatty acids, which help support a balanced immune response and reduce inflammation markers. . Recently when I was sick with a cold I was taking “Cold-Eaze” lozenges and noticed better sleep and improved functions. If you want to lessen the risk of adding pounds, retaining fluid or raising blood sugar or BP, here are some foods to avoid while on steroids — and a few things worth adding to your diet. Ace Inhibitors, which are used to treat elevated blood pressure, may cause zinc deficiency in your blood, as well as zinc-lowering drugs such as Captopril and Zestril. 5 days ago · Prednisone Overview. Serum zinc levels lower than 50 mcgg/dl at admission correlated with worse clinical presentation, longer time to reach stability and higher mortality. Zinc plus lozenges is in the drug class vitamin and mineral combinations. Both alcohol and prednisone can also weaken your bones with prolonged use, potentially causing osteoporosis. Participants received prednisone or anakinra plus zinc. Talk to your doctor if you have any questions or concerns. Megan Milne, PharmD, BCACP, is an award-winning clinical pharmacist board certified in the types of conditions people take prednisone for. Jul 25, 2024 · Discover safe, effective Natural Alternatives to Prednisone for managing chronic inflammation. Zinc is a nutritional supplement. Follow-up lab tests confirmed that Kathy was deficient in three essential minerals: magnesium, potassium and zinc. Causes of macrocytic/megaloblastic anaemia. Sep 19, 2024 · BACKGROUND AND AIMS: In a recent trial, patients with severe alcohol-associated hepatitis treated with anakinra plus zinc (A+Z) had lower survival and higher acute kidney injury (AKI) rates versus prednisone (PRED). What is Prednisone? Prednisone has active ingredients of prednisone. Check Zicam in the real world. ” Zinc can help maintain strong bones and healthy mood. After a bad reaction to prednisone I’ve been sleeping poorly and had some other issues. People who take a lot of zinc supplements may develop a copper deficiency. 0 mg prednisone/kg body weight per day. If you take amiloride, do not take zinc supplements as it may raise the zinc levels in your blood. Warnings Aug 19, 2024 · Patients (N=147) with sAH were randomly assigned 1:1 to receive 40 mg oral prednisone for 30 days plus subcutaneous placebo for 14 days and oral placebo for 90 days (n=73) or 100 mg subcutaneous anakinra for 14 days and 220 mg oral zinc for 90 days plus oral placebo for 30 days (n=74). A total of 604 drugs are known to interact with prednisone. Are you looking to buy Prednisone online? Whether you need 20mg, 10mg, or 5mg tablets, it's essential to understand what Prednisone is, how it works, and the considerations you should make before placing an order. 5 mg or 2. Check Prednisone in the real world. 45 was a stopping rule for prednisone/ prednisone placebo. A small, controlled study found that intravenous (iv) glycyrrhizin (an active constituent in licorice) given with iv prednisolone prolonged prednisolone action in healthy men. I noticed they have 13mg of Zinc Gluconate but see other types available as well. One of the things that you should be aware of is prednisone and your food intake. This report displays the potential drug interactions for the following 2 drugs: prednisone; Zinc (zinc sulfate) Edit list (add/remove drugs) Consumer; Professional; Interactions between your drugs Prednisone or prednisone placebo was stopped if Day-7 Lille score was >0. 92 Long-term use of prednisone and other anti-inflammatory steroids can both inhibit the absorption of calcium and increase renal calcium loss, thus having an unfavorable Feb 26, 2021 · If you've been prescribed prednisone or a related steroid, these pills may cause some nutritional side effects. It is recommended to avoid turmeric supplements while on prednisone to ensure proper treatment. An ENT put him on Prednisone for a few weeks (no help). Jan 18, 2023 · Eligible patients enrolled in the study were randomized to anakinra, 100 mg subcutaneous injection for 14 days, plus zinc sulfate 220 mg for 90 days, vs. Since our winter here in eastern Ontario started I have had three almost concurrent colds and other than taking daily zinc and vitamin C supplements, I am wondering if there is anything else that would safely boost my suppressed immune system. Reduced height attainment was BACKGROUND & AIMS In a recent trial, patients with severe-alcohol-associated-hepatitis (sAH) treated with anakinra-plus-zinc (A+Z) had lower survival and higher acute-kidney-injury (AKI) rates versus prednisone (PRED). METHODS: In this phase IIb double-blind randomized trial in adults with SAH and MELD scores of 20-35, participants were randomized to receive either For example, folate deficiency may occur in patients who are receiving sulfasalazine, and supplementation with folic or folinic acid is recommended to replenish folate stores. We look at the type of foods you can eat along with If this action happens in people, it might prolong prednisone activity and possibly increase prednisone-related side effects. All study drugs were stopped for uncontrolled infection or ≥5 point increase in MELD score. Medications that impact prednisone’s effectiveness, like phenytoin The modifications in plasma, erythrocyte and urine zinc and copper concentrations induced by chronic or acute corticotherapy were studied in patients suffering from rheumatoid arthritis and the results compared with those from controls. eHealthMe is studying from 636,757 Prednisone users for the drug's side effects, drug interactions, effectiveness and more. Sep 19, 2024 · We assessed the efficacy and safety of a combination of anakinra, an IL-1 antagonist, plus zinc (A+Z) compared to prednisone using the Day-7 Lille score as a stopping rule in patients with SAH. Sep 1, 1984 · It contained i00 ppm zinc and 1. It is common for prednisone to be prescribed for other indications or in a different dosage than shown in the label information. Calcium, magnesium and zinc is used to treat Vitamin/Mineral Supplementation and Deficiency. The antibiotic, tetracycline, for example, can block absorption by binding with minerals, such as calcium, magnesium, iron and zinc in the GI tract. This medication is available only by prescription. ” Using predniSONE together with diclofenac may increase the risk of side effects in the gastrointestinal tract such as inflammation, bleeding, ulceration, and rarely, perforation. In the case of these two supplements, zinc wins. Jun 16, 2023 · For instance, those who are having regular treatments of prednisone may benefit from additional calcium intake since chronic prednisone use increases risk for bone loss or osteoporosis. The primary endpoint was overall survival at 90 days. Prednisone-induced weight gain can worsen the original condition for which prednisone was prescribed, such as types of arthritis, putting an even greater burden on joints already in pain. 2% calcium. If zinc sulfate causes stomach irritation, you can try another form, such as zinc citrate. (2) Weight loss drugs and cholesterol-lowering medicines similarly bind to fats, preventing them from being absorbed. Glucocorticoid therapy for 28 days improves 30- but not 90-day survival. Drug Interactions between prednisone and Zinc. Prednisone treatment depressed the capacity of the liver, kidney, muscle, bone and testes to accumulate 65Zn. A total of 102 drugs are known to interact with Vitamin C plus Zinc. 6 mg prednisone per gram of glucose. eHealthMe is studying from 5,298 Zicam users for the drug's side effects, drug interactions, effectiveness and more. It is often used in zinc deficiency. It's important to follow the recommended dosage and not exceed the recommended duration of use. Drug and food interactions May 13, 2024 · Prednisone is a corticosteroid medicine used to decrease inflammation and keep your immune system in check, if it is overactive. It is often used in Prednisone and Zinc: The Side Effects of Low Zinc Levels#prednisone #prednisonesideeffects #steroids #steroidsideeffects #glucocorticoid #zinc #shorts Zinc is a mighty mineral that can help counteract some of the side effects caused by prednisone. Vitamin c plus zinc is in the drug class vitamin and mineral combinations. What is Zinc sulfate? Zinc sulfate has active ingredients of zinc sulfate. Drug Interactions between prednisone and Zinc Gummies. This report displays the potential drug interactions for the following 2 drugs: prednisone; Zinc Gummies (zinc gluconate) Edit list (add/remove drugs) Consumer; Professional; Interactions between your drugs Zinc Plus Lozenges. Based on the lab results, Kathy’s internist agreed to oversee her medications while I supervised her nutritional regimen. There are 249 drugs known to interact with Ofev (nintedanib), along with 6 disease interactions, and 1 alcohol/food interaction. In this double-blind randomized trial, patients with SAH treated with prednisone using the Lille stopping rule on Day 7 had higher 90-day overall and transplant-free survival and lower rates of acute kidney injury compared to patients treated with a combination of anakinra and zinc. Matching placebos for anakinra, zinc, and prednisone were provided to mask the treatment. This report displays the potential drug interactions for the following 2 drugs: prednisone; zinc sulfate; Edit list (add/remove drugs) Consumer; Professional; Interactions between your drugs Oct 5, 2024 · Some people need to take copper due to conditions that cause copper deficiency. Calcium functions in bone mineralization and maintaining an alkaline environment. We assessed the efficacy and safety of a combination of anakinra, an IL-1 antagonist, plus zinc (A+Z) compared to prednisone (PRED) using the Day-7 Lille score as a stopping rule in patients with SAH. " I feel like he is being dismissed because of his age and want to pursue other avenues. Mar 5, 2024 · #shorts #prednisone #prednisonesideeffects #nutrientdeficiency #depletion #zinc *** 💊 Get Prednisone Nutrient Support: https://nutranize. Prednisone is used to treat the following conditions: Acute Lymphocytic Leukemia; Adrenocortical Insufficiency; Allergic Reactions; Allergic Rhinitis; Allergies; Amyloidosis; Ankylosing Spondylitis; Aspiration Pneumonia; Asthma Applies to: prednisone and Sleep+Immune Health (ascorbic acid / cholecalciferol / elderberry / melatonin / zinc sulfate) Information for this minor interaction is available on the professional version . Drug and food interactions Drug Interactions between prednisone and zinc sulfate. 45. May 1, 2024 · There is no approved treatment for severe alcohol-associated hepatitis (SAH). Follow a healthy lifestyle and talk to your provider about your dosage. Of the total drug interactions, 20 are major, and 229 are moderate. Serum zinc decreased significantly from normal pretransplant values to subnormal vaues 1-5 days after … 1 day ago · Prednisone, a corticosteroid commonly prescribed for a wide variety of indications, is considered safe with most cough and cold medications. Zinc is an important mineral for healing. #prednisone #prednisonesideeffects #zinc #nutrientdeficiency The content discusses the impact of prednisone and other medications on zinc levels in the body, Mar 11, 2024 · Alcohol and prednisone share similar side effects, including headache, stomach irritation, and mood changes. Drug Interactions between prednisone and Zinc-220. Dec 11, 2016 · Additionally I discovered that the diuretic she was taking could be depleting her zinc levels. The primary objective of the study is to determine the clinical efficacy and safety of Anakinra (plus zinc Find patient medical information for Vitamin B with Vitamin C and Zinc oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Your doctor may already be aware of the risks, but has determined that this is the best course of treatment for you and has taken appropriate precautions and is Severe alcohol-associated hepatitis (SAH) is associated with high 90-day mortality. We assessed the efficacy and safety of a combination of anakinra, an IL-1 antagonist, plus zinc (A+Z) compared to prednisone using the Day-7 Lille score as a stopping rule in patients with SAH. There are 102 drugs known to interact with Elderberry Gummies with Vitamin C and Zinc (multivitamin with minerals). “COVID-19: Poor outcomes in patients with zinc deficiency. Prednisone was prepared as a premix containing 1. Jan 4, 2025 · Our study demonstrates a correlation between serum zinc levels and COVID-19 outcome. 7. A total of 102 drugs are known to interact with Zinc Plus Lozenges. Prednisone or prednisone placebo was stopped if Day-7 Lille score was >0. Results: Seventy-three participants were randomized to prednisone and 74 to A+Z. 0 mg or 8. He used Flonase, and is now taking zinc. You should take multivitamin with minerals at least three hours after taking cephalexin. steroid therapy, growth, and zinc status in children, measurements of height, zinc and copper in serum and hair, taste acuity, and dietary intakes of energy, protein, zinc, and copper were analyzed for 29 asthmatic, 11 prednisone-treatedasthmatic, and 21 non-asthmaticsub­ jects, 6 to 20 years old. Cooperman says. According to the CDC, “Zinc is a mineral that promotes immunity, resistance to infection, and proper growth and development of the nervous system. Day-7 Lille score >0. Dr. Patients not treated with corticosteroids had low plasma zinc a … Dr. Jan 1, 2018 · I have PMR and currently taking 8 mg prednisone per day - slowly decreasing. Megan Milne, PharmD, BCACP Dr. The trial was stopped early after a Drug Interactions between prednisone and zinc gluconate. However, there is considered to be an interaction between prednisone and NSAIDs (non-steroidal anti-inflammatory drugs) and the use of both together is generally recommended to be avoided. General adverse events. Potassium plays a role in sodium balance, blood pressure control and hypertension. This article discusses the benefits, dosage, types, and side effects of zinc supplements. Learn about curcumin, green tea, zinc, and more evidence-based options to reduce steroid dependence. prednisone. Severe alcohol-associated hepatitis (SAH) is associated with high 90-day mortality. Drug Interactions between prednisone and zinc chloride. Megan had to take prednisone herself for an autoimmune condition so understands what it feels like to suffer prednisone side effects and made it her mission to counteract them as the Prednisone May 13, 2024 · Zinc Lozenges: Zinc is known to have antiviral properties and may help reduce the duration and severity of cold symptoms. Calcium, Magnesium and Zinc Interactions. Copper is an essential micronutrient and serves as a cofactor for several enzymes in the synthesis of haemoglobin (ferroxidase), neurotransmitters (dopamine mono-oxygenase), pigments (tyrosinase), the extracellular matrix of the connective tissue (lysil oxidase) and electron transport (cytochrome c oxidase). Prednisone is in the drug class glucocorticoids. 1 5 According to the WHO, the recommended In this double-blind randomized trial, patients with SAH treated with prednisone using the Lille stopping rule on Day 7 had higher 90-day overall and transplant-free survival and lower rates of acute kidney injury compared to patients treated with a combination of anakinra and zinc. Ofev Interactions. Prednisone is used to treat the following conditions: Acute Lymphocytic Leukemia; Adrenocortical Insufficiency Products that contain zinc may interfere with the absorption of cephalexin into the bloodstream and reduce its effectiveness. This multicenter, randomized, double blinded, placebo-controlled clinical trial is focused on novel treatments for severe alcoholic hepatitis (AH), a life-threatening stage of alcoholic liver injury that has a short-term mortality rate much higher than that of other liver diseases. Prednisone is a corticosteroid medication used to treat inflammation and autoimmune disorders. The empirical dosage is 15 mg/kg of elemental zinc per day, (or 200 mg elemental zinc per medium sized dog per day, tapered to 50 to 100 mg per dog per day based on serum zinc levels). Prednisone resulted in better overall and transplant-free survival at 90 days. 6) Jothimani D et al. com/ ***Nutranize Z Background & aims: Severe alcohol-associated hepatitis (SAH) has high 90-day mortality. So, if you take copper and zinc together, one usually has poor absorption. The doctor told him to let him know if the zinc worked, but otherwise there was nothing to be done that wasn't "invasive. Impact and implications There is no approved treatment for severe alcohol-associated hepatitis (SAH). nfaii vkkc zhobqxn xmbuojc ozgvdt gusy gxnc smva brrj crdvnif